A collectin-like protein from tunicates.

Secretion of a collectin-like protein in tunicates is enhanced during inflammatory responses.

The sub-cellular and humoral concentrations of a collectin-like protein from the solitary tunicate, Styela plicata, were measured after in vivo challenge with the inflammatory agent, zymosan. Tunicates were injected with zymosan before hemocytes and serum were harvested, subjected to western blotting and immunostained with an anti-S. plicata collectin antibody to determine the relative titers o...

CL-46, a novel collectin highly expressed in bovine thymus and liver.

Collectins are oligomeric molecules with C-type lectin domains attached to collagen-like regions via alpha-helical neck regions. They bind nonself glycoconjugates on the surface of microorganisms and inhibit infection by direct neutralization, agglutination, or opsonization. During the characterization of the gene encoding bovine CL-43 (43-kDa collectin), we identified a novel collectin-gene. W...

Direct Binding of Toll-Like Receptor 2 to Zymosan, and Zymosan-Induced NF- B Activation and TNF- Secretion Are Down-Regulated by Lung Collectin Surfactant Protein A

stigmata of ascidian tunicates, arranged in paired dorso-ventral columns like the stigmata of ascidian and doliolid

columns like the stigmata of ascidian and doliolid tunicates, while the presumed atria extended far forwards right and left of the stigmata and therefore right and left of the pharynx, as in ascidian tunicates. Furthermore, the atria opened antero-dorsally as in ascidian tunicates, and these anterior openings were paired as in post-larval ascidian tunicates. As a tunicate, Jaekelocarpus probabl...

Assignment of the surfactant protein A gene (SFTPA) to bovine chromosome 28q1.8-->q1.9 by radiation hybrid mapping.

The collectin surfactant protein A (SP-A) is involved in the innate host defense of the lung. It binds to non-self glyco-conjugates on the surface of invading microorganisms. Binding leads to lysis, aggregation and initiation of effector mechanisms that include increased phagocytosis by phagocytic cells and modulation of the inflammatory response (Haagsman, 2002). Across species, the gene encod...